Autoimmune disease dog and cat


Sad look back

©Marc De Bishop


autoimmuunziekte

What I want to talk about here is a particle in my life somewhere that can be named as heartbreaking sad.

As a child, my desire has always been great to have a dog close to me as a loyal friend and companion, but my parents did not share the same animal love as me, thus no dog or even cat came into my life. Kobe was given to me by an uncle, an albino hamster.

Kobe has gone a lot of fun and friendship after 9 years, and had been just about the last pet I've known and had. The busy agendas and many jobs, both nationally and internationally, did not give me the opportunity to combine it with a pet.

During that busy career, I got in touch with a person who knew how to tell me a lot about a spicy dog breed that is not too big and can travel with you very easily, and so on. A French Pyrenean Shepherd Dog I went to visit, and ended up with a hobby breeder on a stone's throw from Tarbes at the foot of the Pyrenees. And frankly, I got into it, the butterflies came back to life and gave me so much satisfaction when looking at the puppies that had just been born. After mailing and talking on the phone, I took the big step: I ordered a female. What exciting.

Must have been in the late 1990s that a house was bought with a large garden, and a dog house would have to be provided there. Because dogs are supposed to stay outside, which is better for their health and wellbeing, that's all going to be fine.

For some reason I didn't manage to pick up Piau from the breeder at the normal age of 14 weeks, she must have been about five months when I started the outbound journey. Little cute, convex fur topped with a really cuddly cup with very sweet eyes. There was a work camp for the breed that was organized by the French club of this exceptional breed that day, and Piau was also enrolled to participate in the puppy rank.

It's a thing or two that day, even my little Piau won the first prize in driving a small herd of goats, fascinating to see. such experiences, and the most beautiful memories too.

The months followed each other as we are still used to now, but I got a flare back when reading Henkjan the Warrior his question. all kinds of autoimmune disease symptoms in mammals, just to call it so. And the dog was also mentioned in between, so you can guess which direction I'm going.

If memory does not let me down, it was beautiful, warm and sunny summer weather, and I would have noticed then my little friend was ever more and more, as if something was stuck in his throat. Not directly to worry about me, so I let it pass.

Piau must have been about 9 months at that time that it really went a bizarre direction with her, she started getting flakes on the nose and really didn't know me any more. I'm sure the vet could tell me more what was going on with my girlfriend. Gullible if I was -also naive- told that doctor she might have contracted a sun allergy, so an ointment would improve quickly, he said and hoped I was.

Believe me free, nothing helped and that prescribed ointment certainly didn't, it only got worse and worse, her nose had turned completely pink, all body parts that normally showed the black pigment were all affected as much, the couching also had become alarming.

The day Piau turned 10 months, I entered a veterinary clinic because it was reported that a highly skilled veterinarian practiced his practice there. Waiting in the room until he came to get me, tears of pain rolled down my cheeks when my little girl looked at me with eyes with little sparkle and flickering. You may come in, Mr. Bishop, I heard him say. What can I do for you?

He listened with attention to my explanation of the facts, and was unable to tell it for sure, but I suspect there are two possibilities; either it is heartworm, or I think of SLE. A biopsy would give an answer to the other, and then there could be further talk about possibilities, but certainly not as a matter of course, be curable. Heartworm is untreatable he already managed to assure me and in a short time it deteriorates very quickly with the dog, resulting in mortality.

The moment of truth had arrived, the result was in. Piau didn't go well.

Look, Mr. Bishop, Piau suffers from Systemic Lupus Erythematosis. Let me explain it to you: ' Dogs with SLE suffer from a variety of problems. Symptoms may occur in various organs, sore joints, crusts on the skin, spontaneous wounds in the mouth, complaints of renal failure or anemia. In general, dogs with SLE show vague symptoms such as decreased activity, varying appetite, sometimes periods of fever and varying lameness. And as you have already listed me several signs, her condition is really dramatic. I can prescribe her a dose of cortisone, but I can tell you that it will be extremely high, which can cause other problems, over time. I quote; ' long-term use of corticosteroids may cause side effects. The animals actually get a form of hyperadreno-corticism or Cushing's syndrome. The animals can slim down and the skin may become brittle. Gastrointestinal problems can also occur, mainly stomach and duodenal ulcers can be a danger. Immunity is suppressed by corticosteroids and this can make animals more susceptible to illness. Because they also affect sugar content, cortisones are not used in animals with diabetes.’ But, fortunately, the latter does not apply to her.

Mind you, dear Marc was able to add the veterinarian, you should consider, how bad it may sound, let Piau fall asleep, which is the best solution for her in this degree of severity. Once the high-dose cortisone cure ends, I can't know for sure if it will completely get rid of it, because the injuries are forever. Regrets even though there is no other remedy for medication.

I followed the advice and good advice of the vet, because my little one really abandoned and did not show any more joy of life, which I had the opportunity to experience with her in the short life. It was very heavy, I can confirm that, even now when writing this post, I get back the head in the throat and the sweat breaks me out. I stayed with her when she got the final syringe, and left life in a quiet way, lying in my arms.

 
This is a rare disease of the autoimmune system. In this disease, the immune system forms antibodies to nuclear parts of its own cells. This can cause a variety of effects, but the most commonly known are arthritis, kidney disease, skin disease and blood abnormalities (e.g. anemia). Many other effects and side effects can also occur, so it is difficult to describe this severe autoimmune disease exactly within lines. In general, it is assumed that this disease is not present unless proven tested to determine whether antibodies form against one's own body and if there are clinical signs or at least 2 of the most common. Even then it's hard to make sure that this disease is the actual problem. Some reactions to drugs and some cancers have almost the same clinical signs and many problems cause these clinical signs as well. Treatment usually calls for immune enhancers with cortisone such as Prednisone.

A number of other autoimmune diseases that can occur in dogs include:

Auto-immune Thryroiditis or Hashimoto Disease Most dogs with hypothyroidism appear to have an autoimmune disease after further examination: Hashimoto's disease. In an autoimmune disease, the body attacks its own cells, in this case, the cells of the thyroid gland. This causes chronic inflammation of the thyroid gland and causes it to almost stop functioning or no longer functioning at all.

    • Sleepiness, more sleep and reduced stamina
    • Weight gain without eating
    • Skin problems, flakes, hair loss and possible symmetrical baldness
    • Fluid accumulation around the head, moisture above the eyes
    • Heart problems such as weak or slow heart beat
    • Balance problems and possible lameness
Feline Hyperthyroidism is very common, especially in older cats over 12 years of age or older. One possible cause of this is commercial feed, along with treats and snacks, often contains a large amount of iodine in it. These large amounts affect the thyroid gland.
  • The functioning of the thyroid gland can be examined with a blood test, the value of the T4 is then looked at, indicating the activity of the thyroid gland. Despite this study, it is often difficult to make a definitive diagnosis. The thyroid gland regulates metabolism (metabolism) but also various cellular functions. Thus, decreased thyroid function can cause a wide range of complaints, which makes it difficult to diagnose correctly.

Demodex mite is naturally present in small numbers in the hair follicles of the dog's skin. The body has an innate defense mechanism that keeps the number of mites within its limits. If the defense mechanism is not yet well developed, the number of mites may increase and skin problems arise. This is usually seen in young dogs, which is why it is also often referred to as puppy scabies. Older dogs can also get demodex sometimes. Certain breeds are particularly sensitive to demodicode, such as the English Bulldog, Pug, Dobermann, Sharpei and certain Terriers.

Diabetes most often occurs in middle-aged dogs. Females have to deal with them more often than males. Certain dog breeds are predisposed to develop diabetes. The clearest symptoms of diabetes include persistent hyperglycemia and glucosuria. In addition, the dogs show polyuria and polydipsia and lose weight. The diagnosis of diabetes is quite simple and is usually made by taking a urinalysis and testing for glucose, supplemented by a blood sampling, which also involves glucose testing. The main pillars of diabetes treatment are administering insulin, diet adjustment, activity and addressing underlying diseases or causes, such as sterilizing intact female animals. Blood sugar levels should be monitored regularly to monitor a diabetic. Dog and cat diabetes .

Discoid Lupus is a relatively common immune disease in which limited lesions occur on the face and ears, although it is also found in the genital region or pads in some dogs. It usually starts with the appearance of a small lesion that is seen as a colorless or red area. Over time, they become ulcers and crusts.

Depending on each case, there will also be pain and itching. We may notice that sunlight worsens symptoms. It seems that there are breeds with a greater tendency to undergo it as the border collie, the German Shepherd or the Siberian husky.

  • Life expectancy of a dog with lupus
    • Lupus in dogs is treatable in the present time, but, in the case of the systemic, its prognosis is reserved, as it depends on the damage it causes in the various organs. The image is especially delicate when the kidneys are affected. Discoid systemic lupus, on the other hand, can usually be treated successfully. Of course, we should not lose sight of the effects of the treatment, because, when the immune system is suppressed to prevent the body from attacking, it also increases the tendency for the dog to suffer from other diseases without defenses, especially bacterial, that the picture complicates.

    Inflammatory Bowel Disease or Inflammatory Bowel Disease (IBD) is a condition in which your dog's intestine or digestive tract becomes constantly inflamed. The persistent inflammation damages the lining of their digestive tract in a way that prevents food from being digested properly. It can also lead to other health problems if nutrients are not absorbed as should. Although symptoms are similar for IBD and irritable bowel syndrome (IBS), the two conditions are very different. Inflammatory bowel disease is a physical abnormality - the presence of an overgrowth of abnormal inflammatory cells. Irritable bowel syndrome is usually caused by stress, diet changes or infection, and especially affects the colon.

    Grave's Disease Graves' disease in dogs is a condition caused by a hyperactive thyroid gland and will occur in dogs with hyperthyroidism. The condition is considered autoimmune and the immune system will produce antibodies in response to the thyroid hormones. The disease is rare in dogs, but may have complex manifestations. Treatment options may vary and focus on reducing the activity of the immune system on the one hand and reducing the amount of thyroid hormones produced. Graves' disease is caused by an excess of thyroid hormones. The immune system is also involved in the disease, as it will react to this excess of hormones by producing certain antibodies. It is believed that the response of the immune system is caused by the presence of certain bacteria or viruses. It is believed that the disease is hereditary.

      • However, there is no known treatment for this condition. Different treatments can be tested and the dog needs to be checked to see if the treatment works.
      • The activity of the immune system can be monitored with corticosteroids such as prednisone, which will suppress the secretion of any antibodies. However, the treatment will also make the dog more vulnerable to disease, as the immune system plays an important role in the defense mechanism of the dog's body.
      • Thyroid hormones can be controlled by administering medications such as carbimazole, which will reduce thyroid activity. The veterinarian may also recommend surgically removing 1 lobe of the thyroid gland or only parts of the gland. Radioiodine therapy is also a treatment option and can give lasting results.
    Hemophilia There may be two types of haemophilia in dogs: type A hemophilia or type B hemophilia.

      • Hemophilia type A is the most common type of hemophilia in dogs. It passes from a hereditary disease resulting from the mutation (sometimes spontaneous but often familial) of the gene encoding factor VIII. This mutation causes a quantitative or qualitative deficiency of this glycoprotein, which plays a very important role in the cascade of blood clotting, so dogs carrying the mutation have blood that does not clot correctly. The gene for factor VIII is on the X sex chromosome and the condition is passed on recessively, so usually males that express the disease! Females are usually asymptomatic carriers (or show moderate hemorrhagic signs) unless they are homozygous for this mutation, but this case is extremely rare. Some breeds are known to be genetically susceptible to this disease. It's about German Shepherd, German Short-Haired Pointer, Boxer and Long Haired Collie.
      • Type B hemophilia, also known as Christmas sickness, is linked to a factor IX deficiency. Like hemophilia type A, it is a hereditary genetic disease that is transmitted in a gonosomal recessive manner. It therefore more often affects males and certain predisposed dog breeds such as the Malamute, the 'Airedale Terrier, the Rhodesian Ridgeback, the Labrador, the Cocker, the Bichon Frisé or even the Shetland Shepherd Dog. Type B hemophilia is much less common than type A.
      • There is no cure for hemophilia.

    Pannus also known as chronic superficial keratitis, is an eye disease that can lead to blindness if not treated. Pannus is a lifelong problem that can usually be managed but cannot be cured. Pannus is more common and more severe at high altitudes and in areas with severe air pollution. It is widely believed to be an immune-mediated condition, possibly in response to exposure to ultraviolet light or other irritants. Genetic factors may play a role in German Shepherd Dog (GSD) and GSD mix dogs. A variation of pannus can affect the third eyelid and is called nictitans plasmacytic conjunctivitis or plasmoma. Corneal pannus and plasmoma may occur together or alone. Pannus is most common among GSD and GSD mix dogs, but it occurs sporadically in the greyhound, Rottweiler, Belgian Shepherd, Belgian Tervuren and several other breeds. An eye examination can diagnose pannus.

    Pemfigus Is a medical name for a whole group of autoimmune problems that are known for the negative health effects they have on the skin areas of the pet (usually dogs) and with a number of frequency mucous membranes in the body. Result blisters or eruptions of the skin or affected membranes will likely result in significant discomfort and varied levels of powerlessness for the unhappily affected dog (or occasional cat). Pemphigus Foliaceus is the most common of these immune-mediated skin diseases. In this form, the separation of granular cells can cause sores or crusts, usually around the eyes, ears, foot pads, groin and across the bridge of the nose. The Akita appears to be particularly susceptible to the development of this condition. In cats, lesions often occur in the toenails, causing crunchy, sore feet. Pemphigus foliaceous is usually spontaneous, but can also be caused by drugs or may result from years of chronic skin disease. Again, these are considerably complicated issues and can therefore be fairly difficult to solve.

    Perianal Fistulas are best described as small or slightly larger, a little deeper 'cavities', which form 'just' in the skin around the anus. These 'cavities' then show no tendency to cure; in many cases they only gradually increase and/or increase in numbers. It is a chronic condition in almost all cases, which often does not respond or insufficiently to conventional treatments. The onset of perianal fistulas is an immune-mediated condition. It has traditionally been a persistent complaint, usually constantly painful for the dog, reason for despair on the part of the owner and a headache file for the veterinarian. From years of experience, it has been known that immunity problems, more or less noticeable impaired bowel health and chronic analsac inflammation are important causes of perianal fistulas onset and therapy resistance. Notice that your dog licks violently around the anus or makes it turn out to be in a lot of pain.? May your dog suffer from Perianal fistulas (also called anal furunculosis). So be sure to consult your vet.

    Poly arthritis symptoms of arthritis in dogs range from mild to severe. In fact, many owners don't even realize that their dogs have arthritis until it gets severe. This does not mean that these dogs do not feel mild to moderate pain in the early stages, just that they don't show it as a human might. Remember that dogs tend to hide their discomfort as part of their survival instinct. This is part of the reason that routine veterinary examinations are so important, especially as your dog gets older. A veterinarian can detect subtle signs of arthritis during an exam that might otherwise go unnoticed at home. The following are the most common symptoms of arthritis in dogs:

      • Lameness/abnormal walking pattern
      • Stiffness, especially after waking up
      • Reluctance to go up stairs, run or jump
      • Hard to jump in car or furniture
      • Hard sitting or standing
      • Reduced interest in walks, games or participation in other forms of exercise once enjoyed
      • Family revocation
      • Licking a specific joint or joints
      • Sensitivity and pain when touching joints (in severe cases, the pet may scream or even snap)
      • Changes in behavior and/ or posture · Problems getting comfort/ restlessness
      • Sleep more than usual
      • Cracking or grinding of the joint when displaced (called Crepusus, this is usually noted during a veterinary examination)

    Rheumatoid Arthritis or rheumatism in dogs leads to painful joint infections. Symptoms initially appear in batches, but can become chronic. The cause of rheumatism is an autoimmune reaction in the body. The therapy is designed to alleviate symptoms. So far, rheumatism is not cured, but physiotherapy helps to alleviate symptoms. Unlike osteoarthritis, rheumatism in dogs is not caused by gradual wear of the joints. The cause of the painful disease is an autoimmune reaction: in this case, the dog's immune system is directed not only against pathogens, but also against healthy body cells of the articular cartilage. As a result, more and more articular cartilage is broken down and the joint is permanently destroyed. Typical symptoms of rheumatism in dogs include painful, swollen joints. At an advanced stage, the joints may also show deformations. Over time, the affected dog often suffers from muscle loss and associated physical weakness. Other possible signs of rheumatism in dogs include:

      • lame
      • stiffness
      • loss of appetite
      • fevers
      • Swollen lymph nodes

    Luckily rheumatism is relatively rare in dogs. The veterinarian will first clarify if symptoms are due to other joint diseases such as osteoarthritis. To do this, he listens carefully to your dog's medical history. This procedure is called anamnesis and gives the veterinarian first indications indicating rheumatism instead of osteoarthritis. With osteoarthritis, symptoms do not occur in episodes, but start easily and continuously worsen as joint wear increases. Rheumatism therapy is about relieving symptoms and slowing the course of the disease. Unfortunately, the autoimmune disease cannot be cured. To improve your dog's quality of life, the veterinarian prescribes painkillers and anti-inflammatory drugs. The dose is tailored to your dog. This way, the worst symptoms of rheumatism can be alleviated.

    Addison disease is a rare autoimmune disease. In doing so, the immune cells of the body will not focus on foreign invaders, but on the body itself. This way your dog's body causes its own adrenal glands to be destroyed. The result is a shortage of body corticosteroids with all the consequences. Most dogs show only vague symptoms. Only when a large part of the adrenal gland is already damaged will your dog get seriously ill. Addison's disease manifests itself in various forms. This can sometimes take a long time before the correct diagnosis is made. Your dog may vomit regularly, suffer from muscle weakness, intermittent diarrhea, abdominal pain, drowsiness. But sometimes this disease is very acute. Your dog suddenly goes into shock. In this case, it is vital to get to the correct diagnosis and initiate targeted treatment as soon as possible.

    So far as my contribution and research work related to autoimmune disease in both dogs and cats. For additional information, you can delve into the attached links, or at best your veterinarian is the best advisor.

    Then rest me to thank you very much for your visit and interest shown. My next contribution is my life with autoimmune disease, please until then.

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