When the “Ozempic Butt” Shows Up: What Really Happens

The phrase “Ozempic Butt” has gained traction on social media and search engines—not as a medical term, but as a descriptive shorthand for how one’s gluteal (buttock) appearance may change following weight loss on semaglutide‑based therapy (e.g. Ozempic).

Here’s what’s going on:

  • Rapid fat loss: As Ozempic suppresses appetite, delays gastric emptying, and supports weight loss, fat stores throughout the body shrink—including in the buttock region.

  • Skin laxity & elasticity limits: Skin that was stretched by prior adipose tissue may not fully retract, especially in older individuals or where collagen/elastin is reduced.

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