Ozempic (active ingredient: semaglutide ) and Mounjaro (active ingredient: tirzepatide ) are both medications used to treat type 2 diabetes. They have also been shown to be effective in weight loss, making them popular for this use. Below is an overview of the most important differences and similarities:

1. Mechanism of action

  • Ozempic : Is a GLP-1 receptor agonist . It stimulates insulin release in response to increased blood sugar levels, delays gastric emptying and reduces appetite.
  • Mounjaro : Is a dual agonist of GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). It therefore provides an additional mechanism that further improves insulin sensitivity and may have even more powerful effects on blood sugar control and weight loss.

2. Effectiveness

  • Ozempic : Studies show that it is effective in lowering HbA1c (average blood sugar) by approximately 10—18% and can result in weight loss of 6-12% of body weight, depending on dosage.
  • Mounjaro : Show greater effects in clinical trials. It lowers HbA1c by 20% or more and results in weight loss of up to 15-22%, depending on the dose.

3. Administration

  • Ozempic : Administer once a week by subcutaneous injection.
  • Mounjaro : Also once a week by subcutaneous injection.

4. Side effects

  • Ozempic : Common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation. These usually decrease over time.
  • Mounjaro : Has a similar side effect profile, but some users report more gastrointestinal complaints due to the combined effect on GLP-1 and GIP.

5. Indications

  • Ozempic : Officially approved for type 2 diabetes and (in another formulation called Wegovy) for weight loss in obese people.
  • Mounjaro : Previously approved for type 2 diabetes, but since today also approved in Belgium for obesity and weight loss.

6. Costs and availability

  • Ozempic : Is widely available and often cheaper than Mounjaro, depending on insurance and country.
  • Mounjaro : May be more expensive and is less widely available in some places because it is relatively new.


Both medications are highly effective for type 2 diabetes and weight loss, but Mounjaro appears to be stronger at lowering blood sugar and promoting weight loss. However, Ozempic can be a more accessible and tried and tested choice. The choice depends on individual factors such as medical history, tolerance to side effects and costs.
Since Ozempic was discovered by people who want to lose weight, there has been a shortage, which will hopefully be updated by the approval of this second medicine.

Always consult with a doctor to determine which option best suits your situation.

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