How Much Weight Can You Lose in a Month with Ozempic, Mounjaro, or Tesamorelin?

Medications and peptides are changing the way people manage weight. Popular treatments like Ozempic (semaglutide) and Mounjaro (tirzepatide) are widely used, while Tesamorelin, a growth hormone–releasing peptide, is also gaining attention for its ability to reduce abdominal fat.

So how much weight can you lose in a month with these therapies? Let’s break it down.

Ozempic (Semaglutide) – Appetite Control & Steady Results

• How it works: Mimics a natural gut hormone (GLP-1) to regulate appetite, slow digestion, and balance blood sugar.
• First Month: Most patients lose 4–6 pounds in the first month, though some may lose less as the body adjusts.
• Long-Term: Studies show 12–15% of body weight lost over 12–18 months.

Mounjaro (Tirzepatide) – Dual Hormone Action

• How it works: Targets GLP-1 and GIP hormones, making it even more powerful for appetite suppression and metabolic control.
• First Month: Patients often see 6–10 pounds lost within the first month.
• Long-Term: Up to 20% of body weight reduction reported in clinical trials, making it one of the most effective injectable options available today.

Tesamorelin – Fat Loss Peptide Therapy

• How it works: A synthetic peptide that stimulates the release of growth hormone. Unlike Ozempic or Mounjaro, it doesn’t act on appetite but helps reduce visceral (belly) fat and improve metabolism.
• First Month: Some patients notice a 2–4 pound reduction, mainly in abdominal fat.
• Long-Term: Clinical studies show significant reductions in belly fat over 3–6 months, especially in patients with metabolic issues, HIV-related lipodystrophy, or stubborn midsection weight.

What Affects Your Monthly Weight Loss

Your results with Ozempic, Mounjaro, or Tesamorelin depend on: